Iwamura, Tatsunori et al. published their research in Journal of the Chemical Society in 1996 | CAS: 1826-13-7

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Computed Properties of C9H7NS

Reinvestigation of reactions of thiazolium and benzothiazolium N-phenacylides with electron-deficient acetylenes was written by Iwamura, Tatsunori;Kobayashi, Masahiro;Ichikawa, Takashi;Shimizu, Hiroshi;Kataoka, Tadashi. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1996.Computed Properties of C9H7NS This article mentions the following:

Reactions of thiazolium and benzothiazolium N-phenacylides with di-Me acetylenedicarboxylate (DMAD) have been reexamined The thiazolium N-phenacylides generated in situ from 4-methyl- or 5-phenyl-3-phenacylthiazolium bromides with triethylamine, reacted with DMAD in dry DMF to give the thiazole ring-opened products I (R = Me, H; R1 = H, Ph; R2 = H, Br, NO2) in which two mols. of DMAD had been incorporated. The reactions when conducted in both aqueous DMF and in dry DMF in the presence of lithium perchlorate gave the hemithioacetals II which could be transformed into the 1:2 reaction products I of the ylides and DMAD. Benzothiazolium N-phenacylides similarly reacted with DMAD to afford the 1:2 reaction products I (RR1 = CH=CHCH=CH; R2 = H, Br) or the hemithioacetals II. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Computed Properties of C9H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica