Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate was written by Judge, Russell A.;Scott, Victoria E.;Simler, Gricelda H.;Pratt, Steve D.;Namovic, Marian T.;Putman, C. Brent;Aguirre, Ana;Stoll, Vincent S.;Mamo, Mulugeta;Swann, Steven I.;Hobson, Adrian D.. And the article was included in ChemBioChem in 2018.Category: thiazole This article mentions the following:
We describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a structure surrogate to guide compound design. A subset of these mols. also showed robust activity in a cell-based myosin phosphatase assay and in a mech. hyperalgesia in vivo pain model. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4Category: thiazole).
6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica