Palladium-Catalyzed Tandem Ester Dance/Decarbonylative Coupling Reactions was written by Kubo, Masayuki;Inayama, Naomi;Ota, Eisuke;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2022.Computed Properties of C9H7NS This article mentions the following:
“Dance reaction” on the aromatic ring is a powerful method in organic chem. to translocate functional groups on arene scaffolds. Notably, dance reactions of halides and pseudohalides offer a unique platform for the divergent synthesis of substituted (hetero)aromatic compounds when combined with transition-metal-catalyzed coupling reactions. Herein, a tandem reaction of ester dance and decarbonylative coupling enabled by palladium catalysis is reported. In this reaction, 1,2-translocation of the ester moiety on the aromatic ring is followed by decarbonylative coupling with nucleophiles to enable the installation of a variety of nucleophiles at the position adjacent to the ester in the starting material. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C9H7NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica