Computational studies of effective asymmetric alkylation utilizing a chiral Schiff base derived from 2-hydroxy-3-pinanone. Part 1 was written by Matsumoto, Takatoshi;Shiori, Takayuki;Osawa, Eiji. And the article was included in Tetrahedron in 1996.Name: Thiazol-2-ylmethanamine This article mentions the following:
The calculation by the semi-empirical MO method concerning the mechanism of the effective asym. alkylation utilizing a chiral Schiff base derived from 2-hydroxy-3-pinanone (I) has revealed that the factor which controls the stereoselectivity is mainly the influence of the lithium and THF ligands. The results has demonstrated the proposed hypothesis which is based on many experiments In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Name: Thiazol-2-ylmethanamine).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Name: Thiazol-2-ylmethanamine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica