Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization was written by Matter, Hans;Zoller, Gerhard;Herling, Andreas W.;Sanchez-Arias, Juan-Antonio;Philippo, Christophe;Namane, Claudie;Kohlmann, Markus;Pfenninger, Anja;Voss, Marc D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.SDS of cas: 55661-33-1 This article mentions the following:
The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chem. motif that was subsequently optimized to arrive at a chem. series of potent and promising SCD1 inhibitors. In particular, compound SAR224 was selected for further pharmacol. profiling based on favorable in vitro data. After oral administration to male ZDF rats, this compound significantly decreased the serum fatty acid desaturation index, thus providing conclusive evidence for SCD1 inhibition in vivo by SAR224. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1SDS of cas: 55661-33-1).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 55661-33-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica