Synthesis and antimicrobial screening of substituted 2-mercaptobenzothiazoles was written by Murti, Y.;Pathak, D.. And the article was included in Journal of Pharmaceutical Research in 2008.Application In Synthesis of 5-Nitrobenzothiazole-2-thiol This article mentions the following:
The study explores the antimicrobial activity of some 2-mercaptobenzothiazoles and correlates the effect on the antimicrobial potency by varying the substituents in the benzene part of the benzothiazole ring system. Substituted 2-mercaptobenzothiazoles, e.g., I, were prepared by heterocyclization of anilines with carbon disulfide. The synthetic methods used are simple, rapid, and economical and found to be accurate and reproducible. The results of antibacterial and antifungal studies have been found to be satisfactory. Antibacterial activity of the compounds was tested using Escherichia coli, Staphylococcus aureus and Bacillus subtilis and antifungal activity of the compounds was tested using Aspergillus niger and Candida albicans. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0Application In Synthesis of 5-Nitrobenzothiazole-2-thiol).
5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Application In Synthesis of 5-Nitrobenzothiazole-2-thiol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica