Synthesis of N-arylamines in dry media and their antibacterial activity was written by Ramana, M. M. V.;Sharma, Madhu R.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2013.Reference of 1843-21-6 This article mentions the following:
A number of N-aryl amines were synthesized by N-arylation of primary/secondary amines with activated aryl halides in the presence of KF/Al2O3 (basic) dry media at room temperature The newly prepared Compounds were examined for their antibacterial activity against E. coli, S. typhi, B. subtilis, and S. aureus. Some of the compounds showed significant antibacterial activity. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Reference of 1843-21-6).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Reference of 1843-21-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica