Romeo, G. et al. published their research in Pharmazie in 1999 | CAS: 6318-74-7

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 4,5-Diphenylthiazol-2-amine

Synthesis of novel 4,5-diphenylthiazole derivatives as potential acyl-CoA : cholesterol O-acyltransferase inhibitors was written by Romeo, G.;Salerno, L.;Milla, P.;Siracusa, M.;Cattel, L.;Russo, Filippo. And the article was included in Pharmazie in 1999.Recommanded Product: 4,5-Diphenylthiazol-2-amine This article mentions the following:

Several N-(4,5-diphenylthiazol-2-yl)-N’-aryl- or -alkyl-(thio)ureas and N-(4,5-diphenylthiazol-2-yl)alkanamides were prepared as potential acyl-CoA : cholesterol O-acyltransferase (ACAT) inhibitors. Synthesis was accomplished by reaction of 2-amino-4,5-diphenylthiazole with suitable isocyanates, isothiocyanates, or acyl chlorides. Some analogs without a 5-Ph substituent or both the Ph groups in 4- and 5-position of the thiazole ring were also prepared Moreover, some bio-isosteres of the title compounds in which the thiazole ring was replaced by an imidazole were synthesized starting from 2-amino-4,5-diphenyl-1H-imidazole. The ability of synthesized compounds to inhibit ACAT was evaluated in vitro by measuring the formation of cholesteryl[14C]oleate from cholesterol and [1-14C]oleoyl-CoA in rat liver microsomes. Among the tested compounds, only some thiazole ureas were able to inhibit ACAT in a reasonable degree. N-(4,5-diphenylthiazol-2-yl)-N’-[2,6-bis(2-methylethyl)phenyl]urea and N-(4,5-diphenylthiazol-2-yl)-N’-butylurea were the most active compounds in the series showing IC50 values in the low micromolar range. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Recommanded Product: 4,5-Diphenylthiazol-2-amine).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 4,5-Diphenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica