Synthesis and biological evaluation of novel trichodermin derivatives as antifungal agents was written by Zheng, Min;Yao, Ting-Ting;Xu, Xiao-Jun;Cheng, Jing-Li;Zhao, Jin-Hao;Zhu, Guo-Nian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Safety of 2-Methylthiazol-5-amine This article mentions the following:
To discover more potential antifungal agents, 17 novel trichodermin derivatives were designed and synthesized. The structures of all the synthesized compounds were confirmed by 1H NMR, ESI-MS and HRMS. Their antifungal activities against Ustilaginoidea oryzae and Pyricularia oryzae were evaluated. Most of the target compounds showed potent inhibitory activity, in which I showed superior inhibitory effects than the parent compound and com. fungicide prochloraz. Addnl., compound II was found to be active against all tested fungal strains, with EC50 values of 0.47 and 3.71 mg L-1, resp. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7Safety of 2-Methylthiazol-5-amine).
2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of 2-Methylthiazol-5-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica