Month: December 2022

Hamashima, Y. published the artcileSynthesis, biological properties, and pharmacokinetics of 7432-S, a new oral cephem, Related Products of thiazole, the publication is Special Publication – Royal Society of Chemistry (1989), 77-90, database is CAplus.

A number of cephems with ω-carboxyalkenoylamino substituents were prepared and tested for antibacterial activity and oral absorbability. Of these derivatives, the cephem with 7β-(2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoyl)amino] substituent were well absorbed in mice. 7432-S (I) was finally selected as the clin. candidate having antibacterial activity and excellent oral bioavailability.

Special Publication – Royal Society of Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Guzaev, Andrei P. published the artcileReactivity of 3H-1,2,4-dithiazole-3-thiones and 3H-1,2-dithiole-3-thiones as sulfurizing agents for oligonucleotide synthesis, Related Products of thiazole, the publication is Tetrahedron Letters (2011), 52(3), 434-437, database is CAplus.

The reactivity of 5-amino-3H-1,2,4-dithiazole-3-thiones substituted at their amino group and 5-amino-3H-1,2-dithiole-3-thiones substituted at their amino group and C4 toward compounds containing P(III) atoms has been studied. N,N-Di-substituted-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)methanimidamides were selected as novel efficient sulfur transfer reagents suitable for DNA and RNA synthesis.

Tetrahedron Letters published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Azzem, M. Abdel published the artcileElectroactive film of polyaniline substituted with heterocyclic benzothiazole ring, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is European Polymer Journal (1995), 31(2), 205-8, database is CAplus.

Voltammetric studies of 2-(4-aminophenyl)-6-methylbenzothiazole (ABT) were carried out in MeCN and acidic aqueous solutions Potential sweep electrolysis of 0.05 M ABT at a glassy C electrode in MeCN containing 0.1 M LiClO₄ and 0.05 M pyridine produced a polymeric film. The film coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of poly-ABT prepared by constant current electrolysis was 3.8 × 10^-5 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

European Polymer Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Anonymous published the artcilePreparation of amino substituted hydroxyphenyl benzophenone derivatives and their uses as UV filters in sunscreen formulations, Category: thiazole, the publication is IP.com Journal (2003), 3(8), 40, database is CAplus.

Described are synthesis of amino substituted hydroxyphenyl benzophenone derivatives The compounds are useful as UV filters in sunscreen applications. For example, comound I synthesized by reacting anhydrous 4-diethylamino 2-hydroxy benzophenone carboxylic acid with 2,2-dimethyl-1,3-propanediol was found to be a good UV absorber and was incorporated into sunscreen formulations.

IP.com Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Akerfeldt, Stig published the artcileIn vivo antiviral effects of benzothiazole derivatives against various influenza A2 strains, Application In Synthesis of 92-36-4, the publication is Journal of Medicinal Chemistry (1970), 13(5), 1012-13, database is CAplus and MEDLINE.

Seventeen derivatives of benzothiazole were investigated for antiviral activity against various influenza A2 strains in mice. Aminoadamantane was used as an internal standard in the experiments 2-Aminobenzothiazole and 2-amino-4-chlorobenzothiazole gave a protective effect comparable to, or better than, that found for aminoadamantane. Small variations in the structure of these 2 compounds caused a complete disappearance of the antiviral effect. To be effective the active compounds had to be administered in near-toxic doses. All 17 compounds were also tested for antiviral effect against rhino virus 33342, adeno virus 3, and herpes simplex virus. Significant antiviral effect could not be demonstrated for any compound in vitro.

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Abdel Azzem, M. published the artcileElectroactive film of polyaniline substituted with the benzothiazole ring, Application In Synthesis of 92-36-4, the publication is Delta Journal of Science (1993), 17(3), 127-140, database is CAplus.

Voltammetric studies of ring-substituted aniline with a heterocyclic ring , i.e., 2-(4-aminophenyl)-6-methylbenzothiazole (ABT), were carried out in acetonitrile and acidic aqueous solutions Potential sweep electrolysis of 0.05M ABT at a glassy carbon electrode in CH₃CN containing 0.1M LiC10₄ and 0.05M pyridine produced a polymeric film. The film-coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of PABT prepared by constant current electrolysis was 3.8 × 10 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

Delta Journal of Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Peng published the artcileStructure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5, COA of Formula: C14H18BNO2S, the publication is Bioorganic & Medicinal Chemistry (2010), 18(9), 3026-3035, database is CAplus and MEDLINE.

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogs and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC₅₀ range 60-100 nM) in the quinoline series.

Bioorganic & Medicinal Chemistry published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C65H82N2O18S2, COA of Formula: C14H18BNO2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Berry, Craig R. published the artcileCycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1-b]thiazoles, Formula: C4H5NS2, the publication is Organic Letters (2007), 9(21), 4099-4102, database is CAplus and MEDLINE.

Thiazolium azomethine ylides, generated from 1,3-thiazoles equipped with a C-2 methanethiol group, participated in an efficient [3+2] cycloaddition reaction with acetylene derivatives to yield unique pyrrolo[2,1-b]thiazoles. The elimination of the methanethiol leaving group from the cycloadduct replaced the need for a sep. oxidation step and suppressed ring-opening side reactions. Products were obtained in short synthetic sequences to demonstrate their use as a scaffold for compound libraries.

Organic Letters published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wang, Jie published the artcileProcess improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, Quality Control of 5053-24-7, the publication is Hecheng Huaxue (2013), 21(3), 367-369, database is CAplus.

A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, S_N2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C12H19BrS, Quality Control of 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Caiyang published the artcileCesium carbonate-promoted synthesis of aryl methyl sulfides using S-methylisothiourea sulfate under transition-metal-free conditions, Product Details of C4H5NS2, the publication is Organic & Biomolecular Chemistry (2018), 16(34), 6316-6321, database is CAplus and MEDLINE.

In the presence of cesium carbonate, an efficient synthesis of aryl Me sulfides by the reactions of aryl halides with com. available S-methylisothiourea sulfate was developed. This odourless and highly crystalline solid was used as the substitute for malodorous methanethiol. The gram-scale reaction also proceeded smoothly without the use of column chromatog. separation Similarly, 2-(dimethylamino)ethylthio and cyclopropylmethylthio groups were easily introduced into the aromatic rings from the corresponding S-[2-(dimethylamino)ethyl]isothiourea dihydrochloride and S-cyclopropylmethylisothiourea hydrobromide. The possible reaction mechanism was proposed. It was believed that this route to aryl alkyl sulfides were well competitive with currently known methods due to its wide substrate scope, excellent yields, easy operation and transition-metal-free conditions.

Organic & Biomolecular Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C7H3Cl2F3O2S, Product Details of C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica