Chemical constitution and fungistatic action of organic sulfur compounds was written by Davies, W. H.;Sexton, W. A.. And the article was included in Biochemical Journal in 1946.Computed Properties of C13H10N2S This article mentions the following:
The test organisms were Fusarium graminearum Schwabe and Penicillium digitatum Sacc., results being reported with reference to the latter. Compounds tested include metal xanthates, ROCS2M (M = Na, K, Ni, Zn; R = Me, Et, Bu, iso-Bu, Am, dodecyl); Me, Et, and Bu derivatives of (ROCS)2S and (ROCSS)2; tetramethyl- and tetraethylthiuram monosulfides; thiuram disulfides, (RR’NCSS)2 (R,R’ = H; R = H, R’ = Me; R,R’ = Me; R,R’ = Et; R = Ph, R’ = Me; R,R’ = (CH2)5); Me, Bu, PhCH2, 2-hydroxyethyl, allyl dimethyldithiocarbamates; Me, Et, and PhCH2 esters of diethyl-, dicyclohexyl-, pentamethylene-, and phenyldithiocarbamic acids; Me, Et, Pr, iso-Pr, Bu, iso-Bu, dodecyl phenylthiocarbamates; Me p-tolylthiocarbamate and (p-chlorophenyl)thiocarbamate; Et, Bu, Ph, o-, m-, and p-carboxy-, p-hydroxy-, p-acetoxy-, p-amino-, p-acetylamino-, p-dimethylamino-, and p-chlorophenyl thiocyanates; Et, Bu, allyl, Ph, p-tolyl, and p-chloro-, p-methoxy-, m-carboxy-, p-carboxy-, p-hydroxy-, p-acetoxy-, m-acetoxy-, 4-hydroxy-2,6-dimethyl-, 3-chloro-4-hydroxy-, 3-methyl-4-hydroxyphenyl isothiocyanates; 1-HO, 1-HS, 1-MeS, 1-EtS, 1-PrS, 1-HOCH2CH2S, 4-Cl-1-HS, 4-Cl-1-MeS, 5-EtO-1-HS, 5-O2N-1-HS, 1-H2N, 1-MeNH, 1-PhNH, 5-EtO-1-H2N, 1-NCS derivatives of benzothiazole (in this series, the last-named compound was the most active); and the disulfide of 1-mercaptobenzothiazole. The lower xanthates and hydroxyaryl isothiocyanates were the most active compounds, the activity of the latter being equal to that of PhHgOAc, but short of that of EtHgCl. The replacement of S by O in some phenylthiocarbamates and (ROCS)2S compounds did not affect the activity materially. New compounds were: dimethyldithiocarbamates: Bu, b20 157-9°, PhCH2, b20 220°, m. 40-1°, 2-hydroxyethyl, “undistillable liquid,” allyl, b20 140°; Me pentamethylenedithiocarbamate, b10 164-6°, m. 31-2°; tetraethylthiuram monosulfide, m. 33-4°; m-carboxyphenyl thiocyanate, m. 177-9° (decomposition); p-carboxyphenyl thiocyanate, m. 220-1° (decomposition); 3-methyl-4-hydroxyphenyl isothiocyanate, b3 146-9°, m. 52-4°; 3-chloro-4-hydroxyphenyl isothiocyanate, m. 58-9°. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica