Using ‘biased-privileged’ scaffolds to identify lysine methyltransferase inhibitors was written by Kashyap, Sudhir;Sandler, Joel;Peters, Ulf;Martinez, Eduardo J.;Kapoor, Tarun M.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.SDS of cas: 69812-29-9 This article mentions the following:
Methylation of histones by lysine methyltransferases (KMTases) plays important roles in regulating chromatin function. It is also now clear that improper KMTases activity is linked to human diseases, such as cancer. The authors report an approach that employs drug-like ‘privileged’ scaffolds biased with motifs present in S-adenosyl methionine, the cofactor used by KMTases, to efficiently generate inhibitors for Set7, a biochem. well-characterized KMTase. Setin-1, the most potent inhibitor of Set7 the authors have developed also inhibits the KMTase G9a. Together these data suggest that these inhibitors should provide good starting points to generate useful probes for KMTase biol. and guide the design of KMTase inhibitors with drug-like properties. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9SDS of cas: 69812-29-9).
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.SDS of cas: 69812-29-9
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica