Preparation of aminothiazole hydrochlorides was written by Kopp, Marianne. And the article was included in Bulletin de la Societe Chimique de France in 1950.Synthetic Route of C15H12N2S This article mentions the following:
2-Amino-4,5-disubstituted thiazoles are prepared from α-chloro ketones and CS(NH2)2. CS(NH2)2 (1 mole) and the appropriate α-chloro ketone (1 mole) in boiling EtOH (1 l., several hrs.) afford after treatment with alkali the following 2-amino-4,5-disubstituted thiazoles: 2-amino-4,5-diphenyl (hydrochloride, m. 180-3°; picrate, m. 194-5°); 2-amino-4,5-tetramethylene, m. 92-3° (hydrochloride, m. 223-5°); 2-amino-4-phenyl-5-methyl, m. 118°, (hydrochloride, m. 191°); 2-amino-4-phenyl-5-ethyl, m. 93° (hydrochloride, m. 167°); 2-amino-5-phenyl-4-methyl, m. 164-6° (hydrochloride, m. 191°; picrate, m. 235°); and 2-amino-4-methyl-5-benzylthiazole, m. 107° (hydrochloride, m. 175°). In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Synthetic Route of C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica