Synthesis and evaluation of some benzothiazole derivatives as antidiabetic agents was written by Kumar, Sunil;Rathore, D. S.;Garg, Gopal;Khatri, Kapil;Saxena, Rahul;Sahu, Sanjeev K.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2017.Synthetic Route of C7H4N2O2S2 This article mentions the following:
A novel series of benzothiazole derivatives I (R1 = H, CH3, NO2; R2 = H, NO2; R3 = C6H5, p-HOC6H4, p-CH3OC6H4, m-O2NC6H4) were synthesized and subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. All the synthesized derivatives showed significant biol. efficacy. Among the synthesized compounds, I (R1 = CH3; R2 = H; R3 = m-O2NC6H4) at 350 mg/kg exerted maximum glucose lowering effects whereas compound I (R1 = CH3; R2 = H; R3 = p-CH3OC6H4) showed min. glucose lowering effects. All compounds were effective, and exptl. results were statistically significant at p<0.01 and p<0.05 level. From the results, it is clear that compound I (R1 = CH3; R2 = H; R3 = m-O2NC6H4) demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0Synthetic Route of C7H4N2O2S2).
5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Synthetic Route of C7H4N2O2S2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica