Synthesis of 2-amino-4,5-diphenylthiazoles was written by Liu, Wei-wei;Huo, Yun-feng;Zhang, Qiang;Li, Qu-xiang;Wu, Jun;Fang, Qun. And the article was included in Huaxue Shiji in 2014.Electric Literature of C15H12N2S This article mentions the following:
Five 2-hydroxy-1,2-diarylenthanones were synthesized by benzoin condensation with aromatic aldehydes as raw material and the reaction conditions were investigated. The optimized conditions are: n(catalyst) = 20 mol%, n(NaOH) = 10 mol%, and V(H2O) : V(C2H5OH) = 1 : 3 as reagent. The 2-amino-4,5-diarylthiazoles I(R = H, 4-Me, 4-MeO, 2-MeO, 4-Cl, 2-Cl) were synthesized from 2-hydroxy-1,2-diary lenthanones by a two-step reaction of chlorination and cyclization. The structures of were confirmed by IR, 1HNMR and HRMS. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Electric Literature of C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Electric Literature of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica