Novel and Efficient Synthesis of Benzimidazole and Benzthiazole Moieties Mediated by Triflic Anhydride and 2-Nitropyridine was written by Quadri, Syed Aziz Imam;Das, Tonmoy C.;Farooqui, Mazahar. And the article was included in ChemistrySelect in 2017.Computed Properties of C7H4ClNOS This article mentions the following:
In the present report, inter and intramol. C-N bond formation between the carbonyl carbon of urea or amide functional group with various amines, e.g., I, mediated by triflic anhydride and 2-nitropyridine is successfully investigated for the first time. The versatility of the method is demonstrated by exploring it on a wide range of substrates to synthesize diversified 2-aminobenzimidazoles II [Y = NH; R = H; R1 = 4-ClC6H4NH, 1H-pyrazol-1-yl, 1H-indazol-1-yl, etc.], 2-aminobenzothiazoles II [Y = S; R = H, Cl; R1 2-O2N-4-F3CC6H3NH, 4-CN-3-F3CC6H3, [6-cyano-5-(trifluoromethyl)pyridin-3-yl]aminyl, etc.], 2-aminopyridoimidazoles III [R3 = H, Cl; X = N; Z = NH2; R2 = C2H5, (CH3)2CHCH2] and 2-substituted benzimidazoles III [X = CH; R = H; R2 = Me, Et, Pr, (CH3)3CCH2; Z = Cy, furan-2-yl, 4-BrC6H4, etc.]. Short reaction time, high yields and applicability in milder metal free reaction conditions are the highlights of the present methodol. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3Computed Properties of C7H4ClNOS).
6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Computed Properties of C7H4ClNOS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica