Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists was written by Suzuki, Takayoshi;Igari, Sou-ichi;Hirasawa, Akira;Hata, Mie;Ishiguro, Masaji;Fujieda, Hiroki;Itoh, Yukihiro;Hirano, Tatsuya;Nakagawa, Hidehiko;Ogura, Michitaka;Makishima, Makoto;Tsujimoto, Gozoh;Miyata, Naoki. And the article was included in Journal of Medicinal Chemistry in 2008.Application of 1843-21-6 This article mentions the following:
A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor γ (PPARγ) agonist 3. Modification based on the homol. model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biol. of GPR120 and for developing new candidate therapeutic agents. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application of 1843-21-6).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application of 1843-21-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica