Decreased sulfotransferase gene expression in DPT-induced polycystic kidney was written by Tanaka, Yoshihiko. And the article was included in Osaka-shi Igakkai Zasshi in 2001.Safety of 4,5-Diphenylthiazol-2-amine This article mentions the following:
Polycystic kidney is induced by feeding 1% 2-amino-4,5-diphenylthiazole (DPT) to rats. The alteration of gene expressions on the fourth day in this model was investigated with differential display method (DD). Among the bands which showed different intensities on DD, the decreased expression was confirmed by Northern blot anal. Using this PCR product as a probe, mouse kidney cDNA library was screened. Cloned cDNA of 1482 bp contained open reading frame encoding 296 amino acids, which was 94.3% identical to rat SULT1C2 sulfotransferase and was thought to be an isoform of SULT1C2. Mouse SULT1C2 mRNA was abundant in kidneys and stomachs of normal mice. The expression of SULT1C2 mRNA was decreased the day after DPT feeding and was still low after 2 wk. Although the physiol. substrate and function of SULT1C2 have yet to be elucidated, it may be involved with the sulfation of proteoglycans composing the tubular basement membranes. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Safety of 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Safety of 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica