Facile, efficient synthesis of polysubstituted thiazoles via α-nitroepoxides and thioureas was written by Zhao, Donghong;Guo, Shanshan;Guo, Xiao;Zhang, Guolin;Yu, Yongping. And the article was included in Tetrahedron in 2016.Name: 4,5-Diphenylthiazol-2-amine This article mentions the following:
An efficient synthesis of 2,4,5-trisubstituted thiazoles via the reaction of α-nitroepoxides and thioureas under mild conditions was developed. This reaction proceeded well at room temperature, to afford products in excellent yields for a wide range of substrate and a possible mechanism was proposed. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Name: 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica