Synthesis and biological evaluation of analogs of the anti-tumor alkaloid naamidine A was written by Aberle, Nicholas;Catimel, Jenny;Nice, Edouard C.;Watson, Keith G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Synthetic Route of C15H12N2S This article mentions the following:
A small series of analogs, such as I [R4 = CH2C6H4-4-OMe, C6H4-4-Cl, Ph, R5 = CH2C6H4-4-OH; R4 = R5 = C6H4-4-OMe, C6H4-4-OH, Ph] and II, of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core of naamidine A with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Synthetic Route of C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Synthetic Route of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica