Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro was written by Balakrishna, A.;Reddy, M. Veera Narayana;Rao, P. Visweswara;Kumar, M. Anil;Kumar, B. Siva;Nayak, S. K.;Reddy, C. Suresh. And the article was included in European Journal of Medicinal Chemistry in 2011.Quality Control of 2-Methylthiazol-5-amine This article mentions the following:
A new series of tetra-Ph bisphosphonates have been elegantly synthesized by one-pot method and were characterized by elemental anal., FTIR, 1H, 13C, 31P NMR, mass spectra and evaluated for their in vitro anti-bone resorptive activity by inhibiting growth of osteoclasts. Two bisphosphonates showed marked inhibition ratio (8 μM and 10 μM) and emerged as lead compounds All compounds were tested for their antioxidant (DPPH scavenging, reducing power and inhibition of lipid peroxidation). They exhibited potent in vitro antioxidant activity dose-dependently. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7Quality Control of 2-Methylthiazol-5-amine).
2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Quality Control of 2-Methylthiazol-5-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica