Design and Synthesis of New Pyrazole-Based Heterotricycles and their Derivatization by Automated Library Synthesis was written by Fricero, Prisca;Bialy, Laurent;Czechtizky, Werngard;Mendez, Maria;Harrity, Joseph P. A.. And the article was included in ChemMedChem in 2020.COA of Formula: C4H6N2S This article mentions the following:
This work highlighted how a readily assembled N-hydroxyethyl pyrazole trifluoroborate offered rapid access to architecturally distinct 5-6-6- and 5-7-6-fused tricyclic compounds such as I [R = F, NO2, CO2H, etc.] and II [R1 = NEt2, N-morpholino, NHCH2-2-pyridyl, etc.]. This chem. was not only amenable to single compound synthesis, but also to high-throughput experimentation. It give easy access to diverse compound arrays with various physicochem. and ADME profiles by fully automated library synthesis. The combination of the high-throughput experimentation with rapid testing of the compounds in an integrated physicochem. and ADME profiling workflow allowed accelerated design of novel lead compounds in drug-discovery projects. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1COA of Formula: C4H6N2S).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.COA of Formula: C4H6N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica