Similarities between catalase and cytosolic epoxide hydrolase was written by Guenthner, Thomas M.;Qato, Mazen;Whalen, Robert;Glomb, Sallie. And the article was included in Drug Metabolism Reviews in 1989.Synthetic Route of C15H12N2S This article mentions the following:
Cytosolic epoxide hydrolase, measured as trans-stilbene oxide hydrolase activity, was isolated and purified from human and guinea pig liver cytosol. Antiserum to the guinea pig liver preparation reacted strongly with bovine liver catalase. This lack of selectivity of the antiserum was due to catalase contamination of the epoxide hydrolase preparation It was also determined that several com. catalase preparations are contaminated with cytosolic epoxide hydrolase. The human epoxide hydrolase preparation used here contained no detectable catalase contamination, yet antiserum to this protein also cross-reacted slightly with catalase, indicating some intrinsic similarity between the 2 enzymes. It is concluded that catalase and cytosolic epoxide hydrolase contain some similar immunogenic epitopes, and it is surmised that similarities between the subunits of these 2 enzymes may lead to their partial copurifn. Functional similarities between the 2 enzymes are also demonstrated, as several compounds that inhibit catalase also inhibit cytosolic epoxide hydrolase activity in the same concentration range and rank order. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Synthetic Route of C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Synthetic Route of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica