Copper(II)-Mediated Dehydrogenative Cross-Coupling of Heteroarenes was written by Mao, Zhifeng;Wang, Zhe;Xu, Zhaoqing;Huang, Fei;Yu, Zhengkun;Wang, Rui. And the article was included in Organic Letters in 2012.Related Products of 1826-13-7 This article mentions the following:
Cu(OAc)2-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and “green” access to unsym. biheteroarenes bearing structural motifs of substantial utility in organic synthesis. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Related Products of 1826-13-7).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 1826-13-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica