Characterization of AhR agonist compounds in roadside snow was written by Muusse, Martine;Langford, Katherine;Tollefsen, Knut Erik;Cornelissen, Gerard;Haglund, Peter;Hylland, Ketil;Thomas, Kevin V.. And the article was included in Analytical and Bioanalytical Chemistry in 2012.Related Products of 1843-21-6 This article mentions the following:
Aryl hydrocarbon receptor (AhR) agonistic contaminants were identified in roadside snow samples. Snow was collected in Oslo, Norway, and compared to a background sample collected from a mountain area. The water and particulate fractions were analyzed for AhR agonists using a dioxin-responsive, chem. activated luciferase expression (CALUX) cell assay and by gas chromatog. coupled to high-resolution time-of-flight mass spectrometry with targeted anal. for polycyclic aromatic hydrocarbons (PAHs) and broad-spectrum non-target anal. The AhR agonist levels in the dissolved fractions in the roadside samples were between 15 and 387 pg/L CALUX toxic equivalent (TEQCALUX). An elevated AhR activity of 221 pg TEQCALUX per L was detected in the mountain sample. In the particle-bound fractions, the TEQCALUX was between 1350 and 7390 pg/L. One possible explanation for the elevated levels in the dissolved fraction of the mountain sample could be the presence of black carbon in the roadside samples, potentially adsorbing dioxin-like compounds and rendering them unavailable for AhR interaction. No polychlorinated dibenzodioxins and dibenzofurans or polychlorinated biphenyls were detected in the samples; the occurrence of PAHs, however, explained up to 9 % of the AhR agonist activity in the samples, while comprehensive two-dimensional gas chromatog. coupled to mass spectrometry GCxGC-ToF-Ms identified PAH derivatives such as polycyclic aromatic ketones and alkylated, nitrogen sulfur and oxygen PAHs in the particle fractions. The (large) discrepancy between the total and explained activity highlights the fact that there are other as yet unidentified AhR agonists present in the environment. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Related Products of 1843-21-6).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Related Products of 1843-21-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica