Day: January 5, 2023

Interaction of sulfur monochloride with thiocarbamide and thiocarbanilide was written by Sahasrabudhey, R. H.. And the article was included in Journal of the Indian Chemical Society in 1950.Safety of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

S₂Cl₂ (I) with thiourea in CHCl₃ or absolute EtOH gave a yellow solid from which water extracted α,α’-dithiodiformamidine (II); nitrate, m. 138° (decomposition); picrate, m. 154° (decomposition). Alk. hydrolysis of II formed S, thiourea, and NH₂CN. I (2 cc.) in 10 cc. of C₆H₆ or CHCl₃ refluxed 20 min. with 4 g. of CS(NHPh)₂ in 50 cc. of solvent, after evaporation of the solvent and extraction with EtOH, gave 3.6 g. 2-anilinobenzothiazole, m. 159°; Ac derivative, m. 162-3°. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Safety of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Copper(II)-Mediated Dehydrogenative Cross-Coupling of Heteroarenes was written by Mao, Zhifeng;Wang, Zhe;Xu, Zhaoqing;Huang, Fei;Yu, Zhengkun;Wang, Rui. And the article was included in Organic Letters in 2012.Related Products of 1826-13-7 This article mentions the following:

Cu(OAc)₂-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and “green” access to unsym. biheteroarenes bearing structural motifs of substantial utility in organic synthesis. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Related Products of 1826-13-7).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 1826-13-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design and Synthesis of New Pyrazole-Based Heterotricycles and their Derivatization by Automated Library Synthesis was written by Fricero, Prisca;Bialy, Laurent;Czechtizky, Werngard;Mendez, Maria;Harrity, Joseph P. A.. And the article was included in ChemMedChem in 2020.COA of Formula: C4H6N2S This article mentions the following:

This work highlighted how a readily assembled N-hydroxyethyl pyrazole trifluoroborate offered rapid access to architecturally distinct 5-6-6- and 5-7-6-fused tricyclic compounds such as I [R = F, NO₂, CO₂H, etc.] and II [R¹ = NEt₂, N-morpholino, NHCH₂-2-pyridyl, etc.]. This chem. was not only amenable to single compound synthesis, but also to high-throughput experimentation. It give easy access to diverse compound arrays with various physicochem. and ADME profiles by fully automated library synthesis. The combination of the high-throughput experimentation with rapid testing of the compounds in an integrated physicochem. and ADME profiling workflow allowed accelerated design of novel lead compounds in drug-discovery projects. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1COA of Formula: C4H6N2S).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.COA of Formula: C4H6N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Infrared and the near-ultraviolet absorption spectra of guanidine and benzothiazole derivatives was written by Suresh, K. S.;Ramachandran, J.;Rao, C. N. R.. And the article was included in Journal of Scientific & Industrial Research in 1961.Computed Properties of C13H10N2S This article mentions the following:

Infrared and ultraviolet absorption spectra of guanidine and benzothiazole derivatives showed characteristic bands. Mono-, di-, and triphenyl guanidines had bands at 1692, 1647, and 1659 cm.^-1, possibly due to variations of band order with conjugation, while in the ultraviolet region they showed progressively increasing bathochromic shifts. The ultraviolet spectrum of 2-mercaptobenzothiazole (I) in acid and basic media showed a variation in the absorption maximum, possibly due to the 2,3-dihydrobenzathiazole-2-thione structure assumed by I. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

4,6-Substituted-1H-indazoles as potent IDO1/TDO dual inhibitors was written by Yang, Lingling;Chen, Yang;He, Junlin;Njoya, Emmanuel Mfotie;Chen, Jianjun;Liu, Siyan;Xie, Congqiang;Huang, Wenze;Wang, Fei;Wang, Zhouyu;Li, Yuzhi;Qian, Shan. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C10H14N2O4S This article mentions the following:

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35(I) displayed the most IDO1 inhibitory potency with an IC₅₀ value of 0.74 μM in an enzymic assay and 1.37 μM in HeLa cells. Quant. anal. of the Western blot results indicated that I significantly decreased the INFγ-induced IDO1 expression in a concentration-dependent manner. In addition, I showed promising TDO inhibition with an IC₅₀ value of 2.93 μM in the enzymic assay and 7.54 μM in A172 cells. Moreover, I exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that I is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment. In the experiment, the researchers used many compounds, for example, Methyl 2-Boc-aminothiazole-4-carboxylate (cas: 850429-62-8Electric Literature of C10H14N2O4S).

Methyl 2-Boc-aminothiazole-4-carboxylate (cas: 850429-62-8) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C10H14N2O4S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Transmission of substituent effects in heterocyclic systems by carbon-13 nuclear magnetic resonance. Benzothiazoles was written by Sawhney, Shanti N.;Boykin, David Withers. And the article was included in Journal of Organic Chemistry in 1979.Application of 68867-17-4 This article mentions the following:

The carbon-13 NMR spectra of 57 benzothiazoles, including 6-substituted 2-aminobenzothiazoles (I), 6-substituted 2-methylbenzothiazoles (II), 6-substituted benzothiazoles (III), 5-substituted 2-methylbenzothiazoles (IV), and 2-substituted benzothiazoles (V) were determined in (CD₃)₂SO. Single and dual parameter correlations of the chem. shifts with substituent constants were described for C-2 and C-9 of I, II, and III and for C-2 and C-3 of IV. Resonance effects are primarily responsible for the substituent effect on chem. shifts at these carbons. Transmission of substituent effects by the atom is limited, and the primary path of transmission to C-2 is through N. The data from series III and V suggest that transmission of substituent effects from C-2 to C-6 is ∼1/3 less effective than transmission from C-6 to C-2. In the experiment, the researchers used many compounds, for example, Benzothiazole-5-carboxylic acid (cas: 68867-17-4Application of 68867-17-4).

Benzothiazole-5-carboxylic acid (cas: 68867-17-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application of 68867-17-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Similarities between catalase and cytosolic epoxide hydrolase was written by Guenthner, Thomas M.;Qato, Mazen;Whalen, Robert;Glomb, Sallie. And the article was included in Drug Metabolism Reviews in 1989.Synthetic Route of C15H12N2S This article mentions the following:

Cytosolic epoxide hydrolase, measured as trans-stilbene oxide hydrolase activity, was isolated and purified from human and guinea pig liver cytosol. Antiserum to the guinea pig liver preparation reacted strongly with bovine liver catalase. This lack of selectivity of the antiserum was due to catalase contamination of the epoxide hydrolase preparation It was also determined that several com. catalase preparations are contaminated with cytosolic epoxide hydrolase. The human epoxide hydrolase preparation used here contained no detectable catalase contamination, yet antiserum to this protein also cross-reacted slightly with catalase, indicating some intrinsic similarity between the 2 enzymes. It is concluded that catalase and cytosolic epoxide hydrolase contain some similar immunogenic epitopes, and it is surmised that similarities between the subunits of these 2 enzymes may lead to their partial copurifn. Functional similarities between the 2 enzymes are also demonstrated, as several compounds that inhibit catalase also inhibit cytosolic epoxide hydrolase activity in the same concentration range and rank order. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Synthetic Route of C15H12N2S).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Synthetic Route of C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thermal analyses and spectral characterization of some synthesized metal(II) Schiff base complexes was written by Jain, Rajendra K.;Mishra, A. P.;Gupta, Priya. And the article was included in Journal of Thermal Analysis and Calorimetry in 2012.Category: thiazole This article mentions the following:

Schiff base metal complexes derived from 2-thiophenecarboxylidine-4-anisidine, 3,4-dihydroxy-5-nitrobenzylidine-2-amino-5-methylthiazole and 3,4-dihydroxy-5-nitrobenzylidine-4-chloroaniline were synthesized and characterized by elemental anal., IR, UV-visible, molar conductance and thermal analyses. The complexes are colored and stable in air at room temperature The complexes exhibit coordination number to be 4 and 6. The thermal behavior of metal complexes shows that the hydrated complexes lose water mols. of hydration in the first and then is immediately followed by decomposition of ligand mols. in the subsequent steps. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7Category: thiazole).

2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Influence of steric factors on the interaction of isomeric phenyloxazoles and phenylthiazoles with microsomal oxidation was written by Smith, Leverett R.;Wilkinson, Christopher F.. And the article was included in Biochemical Pharmacology in 1978.Recommanded Product: 5-Phenylthiazole This article mentions the following:

5-Phenyloxazole (I) [1006-68-4] and 5-phenylthiazole (II) [1826-13-7] showed a high inhibitory activity and low spectral (type II) dissociation (K_s) towards both rat liver microsomal and armyworm midgut preparations 4-Phenyloxazole [20662-89-9] had a high K_s, and 2-phenyloxazole [20662-88-8], 4-phenylthiazole [1826-12-6], 2-phenylthiazole (III) [1826-11-5], benzoxazole [273-53-0], and benzothiazole [95-16-9] showed little spectral interactions with microsomes; none other than III had any significant inhibitory effects. The lack of type II binding by III suggests that its mode of action differs from that of I and II. The results are consistent with the steric model developed previously with the imidazoles. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Recommanded Product: 5-Phenylthiazole).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: 5-Phenylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome was written by Zhang, Zaihui;Sun, Shaoyi;Kodumuru, Vishnumurthy;Hou, Duanjie;Liu, Shifeng;Chakka, Nagasree;Sviridov, Serguei;Chowdhury, Sultan;McLaren, David G.;Ratkay, Leslie G.;Khakh, Kuldip;Cheng, Xing;Gschwend, Heinz W.;Kamboj, Rajender;Fu, Jianmin;Winther, Michael D.. And the article was included in Journal of Medicinal Chemistry in 2013.Name: Thiazol-2-ylmethanamine This article mentions the following:

Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from saturated fatty acids. Studies have demonstrated that rodents lacking a functional SCD1 gene have an improved metabolic profile, including reduced weight gain, lower triglycerides, and improved insulin response. In this study, we discovered a series of piperazinylpyridazine-based highly potent, selective, and orally bioavailable compounds Particularly, compound I (XEN103) was highly active in vitro (mSCD1 IC₅₀ = 14 nM and HepG2 IC₅₀ = 12 nM) and efficacious in vivo (ED₅₀ = 0.8 mg/kg). It also demonstrated striking reduction of weight gain in a rodent model. Our findings with small-mol. SCD1 inhibitors confirm the importance of this target in metabolic regulation, describe novel models for assessing SCD1 inhibitors for efficacy and tolerability and demonstrate an opportunity to develop a novel therapy for metabolic disease. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Name: Thiazol-2-ylmethanamine).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Name: Thiazol-2-ylmethanamine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica