Influence of steric factors on the interaction of isomeric phenyloxazoles and phenylthiazoles with microsomal oxidation was written by Smith, Leverett R.;Wilkinson, Christopher F.. And the article was included in Biochemical Pharmacology in 1978.Recommanded Product: 5-Phenylthiazole This article mentions the following:
5-Phenyloxazole (I) [1006-68-4] and 5-phenylthiazole (II) [1826-13-7] showed a high inhibitory activity and low spectral (type II) dissociation (Ks) towards both rat liver microsomal and armyworm midgut preparations 4-Phenyloxazole [20662-89-9] had a high Ks, and 2-phenyloxazole [20662-88-8], 4-phenylthiazole [1826-12-6], 2-phenylthiazole (III) [1826-11-5], benzoxazole [273-53-0], and benzothiazole [95-16-9] showed little spectral interactions with microsomes; none other than III had any significant inhibitory effects. The lack of type II binding by III suggests that its mode of action differs from that of I and II. The results are consistent with the steric model developed previously with the imidazoles. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Recommanded Product: 5-Phenylthiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: 5-Phenylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica