Programmed synthesis of arylthiazoles through sequential C-H couplings was written by Tani, Satoshi;Uehara, Takahiro N.;Yamaguchi, Junichiro;Itami, Kenichiro. And the article was included in Chemical Science in 2014.Computed Properties of C9H7NS This article mentions the following:
A programmed synthesis of arylthiazoles (2-aryl, 4-aryl, 5-aryl, 2,4-diaryl, 2,5-diaryl, 4,5-diaryl, and 2,4,5-triaryl) via palladium or nickel catalyzed sequential C-H couplings of unfunctionalized thiazole using eleven distinct synthetic routes was discussed. This methodol. led to the synthesis of over 150 arylthiazoles including fatostatin (SREBP inhibitor). In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Computed Properties of C9H7NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica