Yang, Lingling et al. published their research in Bioorganic & Medicinal Chemistry in 2019 | CAS: 850429-62-8

Methyl 2-Boc-aminothiazole-4-carboxylate (cas: 850429-62-8) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C10H14N2O4S

4,6-Substituted-1H-indazoles as potent IDO1/TDO dual inhibitors was written by Yang, Lingling;Chen, Yang;He, Junlin;Njoya, Emmanuel Mfotie;Chen, Jianjun;Liu, Siyan;Xie, Congqiang;Huang, Wenze;Wang, Fei;Wang, Zhouyu;Li, Yuzhi;Qian, Shan. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C10H14N2O4S This article mentions the following:

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35(I) displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 μM in an enzymic assay and 1.37 μM in HeLa cells. Quant. anal. of the Western blot results indicated that I significantly decreased the INFγ-induced IDO1 expression in a concentration-dependent manner. In addition, I showed promising TDO inhibition with an IC50 value of 2.93 μM in the enzymic assay and 7.54 μM in A172 cells. Moreover, I exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that I is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment. In the experiment, the researchers used many compounds, for example, Methyl 2-Boc-aminothiazole-4-carboxylate (cas: 850429-62-8Electric Literature of C10H14N2O4S).

Methyl 2-Boc-aminothiazole-4-carboxylate (cas: 850429-62-8) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C10H14N2O4S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica