Palladium-Catalyzed Decarboxylative Cross-Coupling Reaction Between Heteroaromatic Carboxylic Acids and Aryl Halides was written by Bilodeau, Francois;Brochu, Marie-Christine;Guimond, Nicolas;Thesen, Kris H.;Forgione, Pat. And the article was included in Journal of Organic Chemistry in 2010.Safety of 5-Phenylthiazole This article mentions the following:
A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics E.g., in presence of bis(tri-tert-butylphosphine)palladium, reaction of 1-methyl-2-pyrrolecarboxylic acid and PhBr gave 88% 1-methyl-2-phenylpyrrole. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Safety of 5-Phenylthiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of 5-Phenylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica