Ferulic acid and benzothiazole dimer derivatives with high binding affinity to β-amyloid fibrils was written by Byeon, Seong Rim;Jin, Yun Jung;Lim, Soo Jeong;Lee, Ji Hoon;Yoo, Kyung Ho;Shin, Kye Jung;Oh, Seung Jun;Kim, Dong Jin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Related Products of 80945-86-4 This article mentions the following:
New ferulic acid and benzothiazole dimer derivatives were synthesized and evaluated by in vitro competition assay using [125I]TZDM for their specific binding affinities to Aβ fibrils. In particular, one compound (I) showed the most excellent binding affinity (Ki = 0.53 nM), compared to PIB (Ki = 0.77 nM), for benzothiazole binding sites of Aβ1-42 fibrils. This result suggests a possibility of a potential AD diagnostic probe for detection of Aβ fibrils. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4Related Products of 80945-86-4).
6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 80945-86-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica