Crowley, Vincent M. et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 55661-33-1

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold was written by Crowley, Vincent M.;Khandelwal, Anuj;Mishra, Sanket;Stothert, Andrew R.;Huard, Dustin J. E.;Zhao, Jinbo;Muth, Aaron;Duerfeldt, Adam S.;Kizziah, James L.;Lieberman, Raquel L.;Dickey, Chad A.;Blagg, Brian S. J.. And the article was included in Journal of Medicinal Chemistry in 2016.Related Products of 55661-33-1 This article mentions the following:

(Arylmethyl)imidazolylethyl chlorodihydroxybenzoates I (R = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-IC₆H₄, 4-MeC₆H₄, 4-EtC₆H₄, 4-i-PrC₆H₄, 4-NCC₆H₄, 4-HCCC₆H₄, 4-F₃CC₆H₄, 4-PhC₆H₄, 4-MeOC₆H₄, 3,4-Cl₂C₆H₃, 1-naphthyl, 2-naphthyl, 5-quinolinyl, 3-FC₆H₄, 3-ClC₆H₄, 3-BrC₆H₄, 3-IC₆H₄, 3-MeOC₆H₄, 3-MeC₆H₄, 3-PhC₆H₄, 2-FC₆H₄, 2-ClC₆H₄, 2-BrC₆H₄, 2-MeC₆H₄, 2-H₂NC₆H₄, 2-MeOC₆H₄, 2-EtC₆H₄, 2-EtOC₆H₄, 2-i-PrOC₆H₄, 2-n-PrOC₆H₄, 2-F₃CC₆H₄, 2-MeO-4-MeC₆H₃, 3-furanyl, 2-furanyl, 5-Me-2-furanyl, 5-Cl-2-furanyl, 3,5-dimethyl-2-furanyl, 2-thienyl, 3-thienyl, 5-Me-2-thienyl, 5-Cl-2-thienyl, 4-Cl-2-thienyl, 3-Cl-2-thienyl, 5-isoxazolyl, 2-thiazolyl, 3-vinyl-2-thienyl, 3-vinyl-2-furanyl, 3-Et-2-thienyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 5-pyrimidinyl) were prepared as selective inhibitors of glucose regulated protein 94 (Grp94), the endoplasmic reticulum-resident isoform of the heat shock protein 90 (Hsp90), for potential use in the treatment of glaucoma and cancer; the effect of the aryl substituents on Grp94 binding and selectivity was determined I were prepared by the cyclocondensation of a bissilylated chloro(oxopropyl)dihydroxybenzoate with glyoxal and arylmethylamines RCH₂NH₂ (R = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-IC₆H₄, 4-MeC₆H₄, 4-EtC₆H₄, 4-i-PrC₆H₄, 4-NCC₆H₄, 4-HCCC₆H₄, 4-F₃CC₆H₄, 4-PhC₆H₄, 4-MeOC₆H₄, 3,4-Cl₂C₆H₃, 1-naphthyl, 2-naphthyl, 5-quinolinyl, 3-FC₆H₄, 3-ClC₆H₄, 3-BrC₆H₄, 3-IC₆H₄, 3-MeOC₆H₄, 3-MeC₆H₄, 3-PhC₆H₄, 2-FC₆H₄, 2-ClC₆H₄, 2-BrC₆H₄, 2-MeC₆H₄, 2-H₂NC₆H₄, 2-MeOC₆H₄, 2-EtC₆H₄, 2-EtOC₆H₄, 2-i-PrOC₆H₄, 2-n-PrOC₆H₄, 2-F₃CC₆H₄, 2-MeO-4-MeC₆H₃, 3-furanyl, 2-furanyl, 5-Me-2-furanyl, 5-Cl-2-furanyl, 3,5-dimethyl-2-furanyl, 2-thienyl, 3-thienyl, 5-Me-2-thienyl, 5-Cl-2-thienyl, 4-Cl-2-thienyl, 3-Cl-2-thienyl, 5-isoxazolyl, 2-thiazolyl, 3-vinyl-2-thienyl, 3-vinyl-2-furanyl, 3-Et-2-thienyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 5-pyrimidinyl) followed by desilylation. I (R = 2-MeO-4-MeC₆H₃CH₂, 5-chloro-2-furanylmethyl) were tested as inhibitors of cell migration in a cancer metastasis model and for their enhancement of the degradation of mutants of the protein myocilin in a glaucoma model. The structures of the lead compound radamide bound to Hsp82 and Grp94 and of I (R = 5-chloro-2-furanyl) bound to the N-terminal domain of Hsp94 lacking its acidic linker were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Related Products of 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica