Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors was written by Gahman, Timothy C.;Herbert, Mark R.;Lang, Henk;Thayer, Angie;Symons, Kent T.;Nguyen, Phan Manh;Massari, Mark E.;Dozier, Sara;Zhang, Yan;Sablad, Marciano;Rao, Tadimeti S.;Noble, Stewart A.;Shiau, Andrew K.;Hassig, Christian A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Safety of Thiazol-2-ylmethanamine This article mentions the following:
A series of imidazole containing thiadiazoles and pyrimidines has been designed and synthesized as dimerization inhibitors of inducible nitric oxide synthase (iNOS). The necessity of key imidazole and piperonyl functionality was demonstrated, and SAR studies led to the identification of compound I, which showed a dose dependent inhibition in multiple pain models, including tactile allodynia induced by spinal nerve ligation (Chung model). In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Safety of Thiazol-2-ylmethanamine).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of Thiazol-2-ylmethanamine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica