Molecular search of new active drugs against Toxoplasma gondii was written by Gozalbes, R.;Galvez, J.;Garcia-Domenech, R.;Derouin, F.. And the article was included in SAR and QSAR in Environmental Research in 1999.Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride This article mentions the following:
Mol. connectivity has been applied to the search of new compounds with activity against the protozoan Toxoplasma gondii, using a stepwise linear discriminant anal. (SLDA) which is able to classify a compound according to its activity either as active or as inactive. Among the selected compounds, andrographolide and dibenzothiophene sulfone stand out, both with IC50 values lower than 1 μg/mL, which are comparable to these of drugs such as sulfamethoxazole, pyrimethamine and trimethoprim, with IC50 values equal to 1.1, 0.04 and 2.31 μg/mL, resp. These results confirm the usefulness of this topol. approach for the selection and design of new-lead drugs active against Toxoplasma gondii. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride).
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica