Maeda, Minoru et al. published their research in Tetrahedron Letters in 1976 | CAS: 1826-13-7

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of 5-Phenylthiazole

The 1:2 molar adducts in the reaction of 5-phenylthiazole and dimethyl acetylenedicarboxylate was written by Maeda, Minoru;Ito, Shigeru;Kojima, Masaharu. And the article was included in Tetrahedron Letters in 1976.Application In Synthesis of 5-Phenylthiazole This article mentions the following:

5-Phenylthiazole with MeO2CCCCO2Me in a 1:2 molar ratio at 60° for 2 hr gave three isomeric products: I (R = CO2Me, R1 = H; R = H, R1 = CO2Me) (II and III, resp.) and IV. III on heating in C6H6 at 130° for 12 hr gave 7.7% II and 32% IV, whereas II gradually isomerized at room temperature or in C6H6 at 130° to give IV. The results indicate that II and III are the initial addition products arising from the same zwitterion intermediate and that IV is produced directly from II. The isomerization of III to II and IV would proceed through the common intermediate and not by successive [1,5]-sigmatropic shifts. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Application In Synthesis of 5-Phenylthiazole).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of 5-Phenylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica