Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis was written by Pesce, Emanuela;Bellotti, Marta;Liessi, Nara;Guariento, Sara;Damonte, Gianluca;Cichero, Elena;Galatini, Andrea;Salis, Annalisa;Gianotti, Ambra;Pedemonte, Nicoletta;Zegarra-Moran, Olga;Fossa, Paola;Galietta, Luis J. V.;Millo, Enrico. And the article was included in European Journal of Medicinal Chemistry in 2015.Name: 6-Bromo-2-chlorobenzothiazole This article mentions the following:
(Arylamino)arylthiazoles such as I were prepared and tested for their ability to correct mutations in the folding and function of the cystic fibrosis transmembrane conductance regulator (CFTR) and to determine general structure-activity relationships for correcting folding (processing) mutations and functional mutations (potentiation) of the CFTR. I acted as both a corrector and potentiator for the CTFR; its efficacy was improved and marked synergy was present when used in combination with the corrector VX-809. Mol. docking of I and two other (arylamino)arylthiazoles to the nucleotide binding domain NBD1 of the CFTR was performed to determine their binding sites to the CTFR. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4Name: 6-Bromo-2-chlorobenzothiazole).
6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Name: 6-Bromo-2-chlorobenzothiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica