Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer was written by Scott, David A.;Aquila, Brian M.;Bebernitz, Geraldine A.;Cook, Donald J.;Dakin, Les A.;Deegan, Tracy L.;Hattersley, Maureen M.;Ioannidis, Stephanos;Lyne, Paul D.;Omer, Charles A.;Ye, Minwei;Zheng, XiaoLan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Electric Literature of C4H6N2S This article mentions the following:
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7Electric Literature of C4H6N2S).
2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Electric Literature of C4H6N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica