A novel synthesis of 2-benzothiazolamine and its derivatives by a nickel(0)-catalyzed reaction of 1,2-aminoiodoarenes with thioureas was written by Takagi, Kentaro. And the article was included in Chemistry Letters in 1986.Synthetic Route of C13H10N2S This article mentions the following:
In the presence of a Ni(0) complex, 1,2-aminoiodoarenes underwent cyclization with thioureas to provide a facile, site-specific, and general synthetic procedure of 2-benzothiazolamine (I) and its derivatives under non-oxidative conditions. Thus, in the presence of catalytic amount of Ni(0) complex, generated in situ from (Et3P)2NiCl2 and NaBH3CN as a reducing agent, o-iodoaniline was treated with thiourea in DMF at 60° 20 h to give 92% I. Similarly prepared were 12 II (R = H, Me, Cl, CF3; R1 = H, Me, Bu, Ph; R2 = H, Me). In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Synthetic Route of C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Synthetic Route of C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica