Mechanisms affecting the development of renal cystic disease induced by diphenylthiazole was written by Torres, Vicente E.;Berndt, Theresa J.;Okamura, Mikio;Nesbit, Julie W.;Holley, Keith E.;Carone, Frank A.;Knox, Franklyn G.;Romero, Juan C.. And the article was included in Kidney International in 1988.Application In Synthesis of 4,5-Diphenylthiazol-2-amine This article mentions the following:
To provide information on the possible influence of hypertension or its treatment on the development of cysts in autosomal dominant polycystic kidney disease, the effects of the sodium content of the diet, DOCA-salt hypertension, renovascular hypertension, and the administration of enalapril or furosemide on the development of 2-amino-4,5-diphenylthiazole (DPT)-induced renal cystic disease were studied in rats. DOCA-salt hypertension caused vascular and glomerular lesions and proteinuria, but it did not enhance the development of cysts. Cystogenesis was enhanced in exptl. conditions where the renin-angiotensin system was activated. On the other hand, suppression of the renin-angiotensin system lessened the development of cysts. This effect might be mediated by intrarenal angiotensin II and its capacity to promote cell growth and to control the postglomerular vascular resistances and the compliance of the renal interstitium. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Application In Synthesis of 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Application In Synthesis of 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica