Experimental model of renal tumors in polycystic kidneys: effects of long-term 2-amino-4,5-diphenylthiazole administration in rats treated with N-ethyl-N-hydroxyethylnitrosamine was written by Tsumatani, Kenichi;Nakagawa, Yoshinori;Kitahori, Yoshiteru;Konishi, Noboru;Uemura, Hirotsugu;Ozono, Seiichiro;Hirao, Yoshihiko;Okajima, Eigoro;Hirao, Kazuya;Hiasa, Yoshio. And the article was included in Toxicologic Pathology in 1997.Category: thiazole This article mentions the following:
The present study was undertaken to examine the effects of long-term 2-amino-4,5-diphenylthiazole (DPT) treatment after initiation of kidney carcinogenesis with N-ethyl-N-hydroxyethylnitrosamine (EHEN) in Wistar rats. One hundred forty-four 6-wk-old male Wistar rats were divided into 6 equal receiving groups: 1000 ppm EHEN or normal tap water for 2 wk followed by 1.06% DPT or basal diet for the subsequent 14 or 30 wk. Controls were maintained without treatment throughout. Subgroups of 6 animals from each group were sacrificed after 8, 16, 24, and 32 wk for histopathol. assessment of lesion development in the kidneys and liver. Animals treated with DPT first developed cystic changes of the kidneys (primarily at the corticomedullary border) after 8 wk of treatment, and these changes progressed with time thereafter. In the groups in which DPT treatment was discontinued after 14 wk, cysts then gradually decreased in size. All tumors detected in the kidneys were histopathol. diagnosed as renal cell adenomas. The tumor multiplicity after 32 wk of treatment was significantly higher in Group I, receiving EHEN + DPT for 30 wk (6.33±4.46), and Group III, receiving EHEN + DPT for 14 wk (3.83±1.57), than in Group V, EHEN alone (1.00±0.58). Renal cell tumors within cysts were only seen in Groups I and III. The general bromodeoxyuridine labeling indexes for the kidneys at week 32 were significantly higher in Group I (55.94±21.08 cells/mm2) and Group III (53.75±12.38 cells/mm2) than in Group V (22.38±6.98 cells/mm2). In conclusion, DPT caused cystic changes in rat kidneys, which, however, gradually decreased in size after the treatment was discontinued, suggesting a reversible nature. DPT clearly also promotes renal tumor development after EHEN initiation, and this effect persists, to a certain extent, even after the insult is removed. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Category: thiazole).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica