Identification of alpha-substituted acylamines as novel, potent, and orally active mGluR5 negative allosteric modulators was written by Yoshikawa, Keita;Ohyama, Tomofumi;Takahashi, Eiki;Numajiri, Yoshitaka;Konno, Mitsuhiro;Moriyama, Masaki;Takemi, Natsumi;Kunita, Kana;Nishimura, Kazumi;Hayashi, Ryoji. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.HPLC of Formula: 89281-44-7 This article mentions the following:
This Letter describes the identification of a series of novel nonacetylenic mGluR5 neg. allosteric modulators based on the alpha-substituted acylamine structure. An initial structure-activity relationship study suggested that I and II might have good in vitro activity. When administered orally, these compounds were found to have an anxiolytic-like effect in a mouse model of stress-induced hyperthermia. In the experiment, the researchers used many compounds, for example, 2-Methylthiazol-5-amine (cas: 89281-44-7HPLC of Formula: 89281-44-7).
2-Methylthiazol-5-amine (cas: 89281-44-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.HPLC of Formula: 89281-44-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica