Tubular basement membrane changes in 2-amino-4,5-diphenylthiazole-induced polycystic disease was written by Butkowski, Ralph J.;Carone, Frank A.;Grantham, Jared J.;Hudson, Billy G.. And the article was included in Kidney International in 1985.Name: 4,5-Diphenylthiazol-2-amine This article mentions the following:
Tubular basement membrane from rats with 2-amino-4,5-diphenylthiazole-induced polycystic renal disease have altered relative quantities of apparently non-collagenous proteins; this may be a possible contributing factor in the cyst formation. An overall increase in the concentration of high-mol.-weight components and a decrease in concentration of low-mol.-weight components were observed Changes which were particularly notable included a 2-fold increase in a component of Mr = 380,000 and a decrease in one of Mr = 55,000 as analyzed without reduction of disulfide bonds. With reduction of disulfide bonds, the Mr = 380,000 component dissociates, whereas the Mr = 55,000 polypeptide does not, and polypeptides of Mr = 245,000 and 145,000 increase â?-fold in concentration These changes take place most rapidly from 4-8 wk of drug administration and remain relatively constant between 8 and 16 wk. If feeding of the drug is discontinued, the distribution of TBM polypeptides normalizes. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Name: 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Name: 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica