Hamann, Mark et al. published their research in Journal of Natural Products in 2007 | CAS: 69812-29-9

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Recommanded Product: 2-Acetamido-4-methylthiazole-5-sulfonyl chloride

Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure-Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease was written by Hamann, Mark;Alonso, Diana;Martin-Aparicio, Ester;Fuertes, Ana;Perez-Puerto, M. Jose;Castro, Ana;Morales, Susana;Navarro, Maria Luisa;del Monte-Millan, Maria;Medina, Miguel;Pennaka, Hari;Balaiah, Akula;Peng, Jiangnan;Cook, Jennifer;Wahyuono, Subagus;Martinez, Ana. And the article was included in Journal of Natural Products in 2007.Recommanded Product: 2-Acetamido-4-methylthiazole-5-sulfonyl chloride This article mentions the following:

Manzamine A and related derivatives isolated from a common Indonesian sponge, Acanthostrongylophora, have been identified as a new class of GSK-3β inhibitors. The semisynthesis of new analogs and the first structure-activity relationship studies with GSK-3β are also reported. Moreover, manzamine A proved to be effective in decreasing tau hyperphosphorylation in human neuroblastoma cell lines, a demonstration of its ability to enter cells and interfere with tau pathol. Inhibition studies of manzamine A against a selected panel of five different kinases related to GSK-3β, specifically CDK-1, PKA, CDK-5, MAPK, and GSK-3α, show the specific inhibition of manzamine A on GSK-3β and CDK-5, the two kinases involved in tau pathol. hyperphosphorylation. These results suggest that manzamine A constitutes a promising scaffold from which more potent and selective GSK-3 inhibitors could be designed as potential therapeutic agents for Alzheimer’s disease. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Recommanded Product: 2-Acetamido-4-methylthiazole-5-sulfonyl chloride).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Recommanded Product: 2-Acetamido-4-methylthiazole-5-sulfonyl chloride

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica