Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents was written by Kamal, Ahmed;Swapna, P.;Shetti, Rajesh V. C. R. N. C.;Shaik, Anver Basha;Narasimha Rao, M. P.;Gupta, Soma. And the article was included in European Journal of Medicinal Chemistry in 2013.HPLC of Formula: 69812-29-9 This article mentions the following:
A number of linezolid-like oxazolidino-sulfonamides were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-pos. and Gram-neg. bacteria and fungal strains. The compounds I (X = O, S) exhibited significant activity, with a MIC value of 2.0-6.0 μg/mL against a panel of Gram-pos. and Gram-neg. bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9HPLC of Formula: 69812-29-9).
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 69812-29-9
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica