Day: February 3, 2023

Determination of acetazolamide in biological fluids by high-performance liquid chromatography was written by Gal, Joseph;Ellis, Philip P.;Rendi, Maris. And the article was included in Current Eye Research in 1981.Related Products of 69812-29-9 This article mentions the following:

A high-performance liquid chromatog. (HPLC) assay for acetazolamide (I) [59-66-5] is presented. A 100-μL sample is mixed with an aliquot of the internal standard solution and the mixture, buffered at pH 4.5, is extracted with Et acetate. The extract is evaporated to dryness and the residue is analyzed by HPLC, using a reverse-phase octadecylsilane column. The wavelength of the detection is 254 nm. The relative standard deviation in the within-day anal. of replicate 10-μg/mL acetazolamide samples in human blood plasma was 6.5%, whereas the between-day relative standard deviation was 7.1%. The procedure was developed for the 1-25 μg/mL acetazolamide concentration range. The internal standard used is similar in chem. structure to acetazolamide and can be readily prepared in one step from a com. available precursor. In addition to blood serum or plasma, the assay can also use aqueous and vitreous human samples. Theophylline and acetaminophen interfere in the assay. The technique was used to determine the concentration of acetazolamide in the blood serum of human volunteers after an oral dose of the drug, and in the aqueous and vitreous humors of rabbits after an i.v. dose of acetazolamide. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Related Products of 69812-29-9).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 69812-29-9

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Relative reactivity of groups bonded to positions 2 and 5 of the thiazole ring was written by Bosco, Marcella;Forlani, Luciano;Todesco, Paolo E.;Troisi, Luigi. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1976.Computed Properties of C9H7NS This article mentions the following:

The substitution of halogen by MeO-, MeS- and PhS- ions and oxidation of phenylsulfinyl to phenylsulfonyl by PhC(O)OOH at positions 2 and 5 of the thiazole ring were studied quant. The ratio of the reactivities of the positions was moderate and the unusual nucleophilic halogen displacement for 5-halothiazoles together with the oxidation of the 5-sulfinyl groups indicated the slightly pos. character of C-5. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C9H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica