Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs was written by Aldrich, Leslie N.;Stoops, Sydney L.;Crews, Brenda C.;Marnett, Lawrence J.;Lindsley, Craig W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 55661-33-1 This article mentions the following:
The first total synthesis of tambjamine K (I) and a library of unnatural analogs was disclosed. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1HPLC of Formula: 55661-33-1).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.HPLC of Formula: 55661-33-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica