Carbene structure of stable acyl (formyl) anion equivalents was written by Hilf, Christof;Bosold, Ferdinand;Harms, Klaus;Lohrenz, John C. W.;Marsch, Michael;Schimeczek, Michael;Boche, Gernot. And the article was included in Chemische Berichte/Recueil in 1997.Application In Synthesis of 5-Phenylthiazole This article mentions the following:
3-Lithiated 4-tert-butylimidazol-2-ylidene and 4-tert-butylthiazol-2-ylidene as well as the ZnBr species of the latter are shown to be stable carbenes by x-ray crystal structure determination The crystal data are confirmed by 13C NMR in solution and quantum-chem. calculations The exceptional stability of these acyl anion equivalent is due to the p(π) stabilization of the carbene C atoms by the adjacent amino (thio) substituents, as is also the case in structurally related stable carbenes recently isolated for the first time by A. J. Arduengo III et al., and in stable nitrenium ions. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Application In Synthesis of 5-Phenylthiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Application In Synthesis of 5-Phenylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica