Antileukemic agents. 3. Synthesis and antitumor activity of N-(2-chloroethyl)-N-nitrosourea derivatives was written by Nakao, Hideo;Fukushima, Masami;Shimizu, Fusaaki;Arakawa, Masao. And the article was included in Yakugaku Zasshi in 1974.Synthetic Route of C4H6N2S This article mentions the following:
Water-soluble derivatives of N-(2-chloroethyl)-N-nitrosourea RNHCON(NO)CH2CH2Cl (R = pyridylmethyl, pyrimidinylmethyl, quinazolinylmethyl, benzimidazolylethyl, etc.) were prepared and their antitumor activity was tested against leukemia L-1210. Most of these compounds showed a high activity. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Synthetic Route of C4H6N2S).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C4H6N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica