Synthesis, characterization and evaluation of antibacterial and antifungal activity of 2-mercaptobenzothiazole and 2-mercaptobenzoxazole derivatives was written by Bhat, R.;Kumbhar, P.;Helavi, V.. And the article was included in Chemistry & Biology Interface in 2019.HPLC of Formula: 58759-63-0 This article mentions the following:
An efficient tandem route for unprecedented three component reaction involving 2-mercaptobenzoxazoles or 2-mercaptobenzothiazoles, salicylic acid and malononitrile was used for the development of new 2-mercapto-chromenopyridine derivatives I [R = H, 5-NO2, 5-SO3H; X = O, S]. The synthesized new derivatives I were characterized by various spectroscopic methods. In addition, compounds I were screened for in vitro antibacterial and antifungal activities against variety of bacterial and fungi strains resp. Some of the synthesized derivatives were existed to be potent antibacterial derivatives against S. aureus, E. coli, P. aeruginosa, B. subtilis, P. vulgaris and antifungal derivatives against C. coffeanum, A. niger, A. terreus and P. notatum. All these findings suggested that I [R = 5-NO2, X = S; R = 5-SO3H, X = O] might be further exploited as a new pharmacophore model for the development of anti-fungal agents. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0HPLC of Formula: 58759-63-0).
5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.HPLC of Formula: 58759-63-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica