1,3-Dipolar cycloaddition reactions of thiazolium and benzothiazolium nitrogen ylides with acetylenic dipolarophiles was written by Chen, Teng Yueh;Liu, Jong Ho;Chen, Kong Ming. And the article was included in Proceedings of the National Science Council, Republic of China, Part A: Physical Science and Engineering in 1989.Recommanded Product: 1826-13-7 This article mentions the following:
Reaction of equimolar amounts of thiazolium and benzothiazolium N ylides with acetylenic dipolarophiles readily gave 1:1 cycloadducts dihydropyrrolo[2,1-b]thiazoles and -benzothiazoles. However, most of them dehydrogenated easily to fully aromatized pyrrolo[2,1-b]thiazoles and pyrrolobenzothiazole. Dihydroazepino[2,1-b]benzothiazole 1:2 cycloadducts were obtained from benzothiazolium N ylide I (R = Ph) and MeO2CC:CCO2Me (II). I (R = OEt) did not form the expected 1:1 cycloadducts with II. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Recommanded Product: 1826-13-7).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Recommanded Product: 1826-13-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica